Okadaic acid (OA) is a marine toxin, a tumor promoter and an inducer of apoptosis. It mainly inhibits protein-phosphatases, protein synthesis and enhances lipid peroxidation.

A potent inhibitor of certain serine/threonine protein phosphatases, targeting the multiple isoforms of PP1 (IC50 = 10-50 nM), both isoforms of PP2A (IC50 = 0.5 nM) and PP3 (IC50 = 4 nM); a very weak inhibitor of PP2B (IC50 > 2 µM); does not inhibit PP2C or other phosphatases. Add to favourites.

Acute Tox. 3; Skin Irrit. 2;. H301, H331, H311, H315. <= 100 %. En specifik hämmare av fosfoserin/treonin proteinfosfatas 1 och 2a. Det är också en potent tumörpromotor. Det produceras av DINOFLAGELLATS och orsakar Okadaic Acid.

It is a potent tumour promoter that is not an activator of protein kinase C, but is a powerful inhibitor of protein phosphatases-1 and -2A (PP1 and PP2A) in vitro. Okadaic acid (OA) is one of the diarrheic shellfish poisons (DSP) produced by the dinoflagellate genera Dinophysis and Prorocentrum. There are a number of chemically different toxins associated with DSP. They are lipophilic and polyether compounds and can be divided into three main groups: EuroProxima Okadaic Acid is a competitive enzyme immunoassay for quantitative analysis of domoic acid in scallop, mussel and oyster samples. General information: High concentrations of shellfish toxins can accumulate in filter feeders such as clams, mussels, and … Okadaic acid is a toxic polyether compound of a C 38 fatty acid (Fig. 1).It is isolated from the black sponge, Halichondria okadai (Kadota), however, it is thought to be produced by marine dinoflagellates that attach to the black sponge.Okadaic is derived from the name of a Japanese educator Yaichiro Okada.

Okadasyra. Engelsk definition. A specific inhibitor of phosphoserine/threonine protein phosphatase 1 and 2a.

Okadaic acid is a marine sponge toxin which potently inhibits certain serine/threonine protein phosphatases. This cell permeable inhibitor targets the multiple isoforms of PP1 (IC 50 = 10-50 nM), both isoforms of PP2A (IC 50 = 0.5 nM) and PP3 (IC 50 = 4 nM). 1,2,3 It is a very weak inhibitor of PP2B (IC 50 > 2 μM) and does not inhibit PP2C or other phosphatases. 1,3 Presumably through these

Search and download thousands of Swedish university dissertations. Full text. Free. The chemicals assessed in the studies included the neurotoxicants methylmercury, okadaic acid and acrylamide, the drug of abuse MDMA (“ecstasy”) and a Talrika exempel på översättningar klassificerade efter aktivitetsfältet av “okadaic acid” – Engelska-Svenska ordbok och den intelligenta översättningsguiden.

Okadaic acid-treatment applied to cultures containing predominantly differentiated chondrocytes (after day 4) did not influence the cartilage formation. 3H-thymidine and bromodeoxyuridine incorporation-assays demonstrated enhanced cell proliferation in the okadaic acid-treated colonies compared to that of the untreated ones.

Standaert ML et al (1999) J Biol Chem 274(20) : 14074-8.

Det är också en potent tumörpromotor. Det produceras av DINOFLAGELLATS och orsakar Okadaic Acid. Reach registration number 5934 Okadaic Acid Toxins, extracted from living sources, solid, n.o.s.
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Okadaic Acid, Prorocentrum sp. Säkerhetsdatabladen för katalogartiklar finnstillgängliga på www.merckgroup.com. Sida 2 av 16. Akut toxicitet, Kategori 3, Oralt, The small subunit ADP-glucose pyrophosphorylase (ApS) promoter mediates okadaic acid-sensitive uidA expression in starch-synthesizing tissues and cells in Okadaic acid and dinophysistoxin-1 (35-methylokadaic acid) induced hyperphosphorylation of a 58 kDa protein in primary human fibroblasts, due to inhibition of The detection limit for toxins of the okadaic acid group, azaspiracids and pectenotoxins was determined to be 6 µg/kg shellfish meat and for yessotoxins 10 µg/kg A.G. Scientific är leverantör för Okadaic acid sodium salt, Prorocentrum concavum. Dessutom Methyl-L-arginine levereras av oss.

Okadaic Acid. Okadaic acid (or okadeic acid, CAS 78111-17-8, C44 H 68 O 13) is produced by dinoflagelates Dinophysis sp. and Prorocentrum lima. Lipophilic okadaic acid is a potent inhibitor of protein phosphorylase phosphatase-1 and -2A in the cytosol of the mammalian cells that dephosphorylates serine and threonine.
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24 mars 2003 — dynamics and management of okadaic acid (diarrhoeic shellfish toxin) in blue mussels, Mytilus edulis” fredagen den 28 mars 2003, kl 10.00.

Okadaic acid-treatment applied to cultures containing predominantly differentiated chondrocytes (after day 4) did not influence the cartilage formation. 3H-thymidine and bromodeoxyuridine incorporation-assays demonstrated enhanced cell proliferation in the okadaic acid-treated colonies compared to that of the untreated ones. Okadaic acid (OA) is one of the most frequent and worldwide distributed marine toxins. It is easily accumulated by shellfish, mainly bivalve mollusks and fish, and, subsequently, can be consumed by humans causing alimentary intoxications.

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Okadaic acid - Okadaic acid, C44H68O13, is a toxin produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and

3H-thymidine and bromodeoxyuridine incorporation-assays demonstrated enhanced cell proliferation in the okadaic acid-treated colonies compared to that of the untreated ones. Okadaic acid (OA) is one of the most frequent and worldwide distributed marine toxins. It is easily accumulated by shellfish, mainly bivalve mollusks and fish, and, subsequently, can be consumed by humans causing alimentary intoxications. OA is the main representative diarrheic shellfish poisoning (DSP) toxin and its ingestion induces gastrointestinal symptoms, although it is not considered Okadaic acid is a naturally occuring polyether toxin produced by marine dinoflagellates. It is a potent and selective inhibitor of protein phosphatases, inhibiting PP2A completely at 1nM and PP1 at higher concentrations (IC 50 =10-15nM). PP2B is much less sensitive to okadaic acid than PP1, while PP2C is … Okadaic Acid is one of the toxins associated with diarrheic shellfish poisoning (DSP).